Cognition-enhancing and neuroprotective effects of hederacolchiside-E from Pulsatilla koreana. Main Anti-tumor Angiogenesis Agents Isolated From Chinese Herbal Medicines. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. We suggest that PKE is a potent anticancer drug candidate for the treatment of thyroid cancer. 2012 Feb;40(2):452-60. doi: 10.3892/ijo.2011.1204. Epub 2016 Dec 28. Pulsatilla Koreana Extract ist ein Extrakt aus der ganzen Pflanze, Pulsatilla koreana, Ranunculaceae INCI function Skin conditioning The INCI function describes solely the purpose of a cosmetic ingredient. Clipboard, Search History, and several other advanced features are temporarily unavailable. SB365, Pulsatilla saponin D suppresses the proliferation of human colon cancer cells and induces apoptosis by modulating the AKT/mTOR signalling pathway. 2 In addition, the plant contains the cytotoxic unsaturated lactone protoanemonin (C 3 H 4 O 2), which is formed by the breakdown of glycoside ranunculin after injury to the plant. Among them, Pulsatilla koreana extract (PKE) has been widely used as an anti-inflammatory agent and for treating dysentery in traditional Korean and Chinese medicine. Pulsatilla saponin D: the antitumor principle from Pulsatilla koreana. Triterpenoid saponins of Pulsatilla koreana root have inhibition effects of tumor necrosis factor-α secretion in lipopolysaccharide-induced RAW264.7 cells. Plants or herb extracts have emerged as a novel approach to controling various diseases, including cancers. Antitumor activity of Pulsatilla koreana saponins and their structure-activity relationship. SB365, Pulsatilla saponin D suppresses proliferation and induces apoptosis of pancreatic cancer cells. Quality control of Pulsatilla koreana based on the simultaneous determination of triterpenoidal saponins by HPLC-ELSD and principal component analysis. SB365 inhibits angiogenesis and induces apoptosis of hepatocellular carcinoma through modulation of PI3K/Akt/mTOR signaling pathway. However, the effect of PKE as a cancer drug candidate has been less reported. SK-PC-B70M from Pulsatilla koreana improves scopolamine-induced impairments of memory consolidation and spatial working memory. Thus, we investigated the effect of PKE on cell growth and its mechanism in anaplastic thyroid cancer (ATC) cells. Anti-inflammatory effects of a methanol extract from Pulsatilla koreana in lipopolysaccharide-exposed rats. The plant requires a well-drained, humus-rich, gritty soil and a sunny position. Two new lignans from the roots of Pulsatilla koreana. NLM The following notes are based on the general needs of the genus Pulsatilla. Taken together, the present study demonstrated that PKE induced apoptosis, as well as inhibiting cell growth and angiogenesis in ATC cells. Apoptotic and anti-angiogenic effects of Pulsatilla koreana extract on hepatocellular carcinoma. Epub 2013 May 13. 2017 Feb;18(1):39-59. doi: 10.2174/1389202917666160803151752. Epub 2018 Oct 31. Epub 2011 Sep 20. In this study, PKE suppressed the growth of ATC cells in a dose-dependent manner. Get the latest research from NIH: https://www.nih.gov/coronavirus. Son MK, Jung KH, Lee HS, Lee H, Kim SJ, Yan HH, Ryu YL, Hong SS.  |  Anti-protozoal efficacy of medicinal herb extracts against Toxoplasma gondii and Neospora caninum. Antitumor activity of Pulsatilla koreana extract in anaplastic thyroid cancer via apoptosis and anti-angiogenesis. Among them, Pulsatilla koreana extract (PKE) has been widely used as an anti-inflammatory agent and for treating dysentery in traditional Korean and Chinese medicine. Pulsatilla koreana is a native perennial plant growing in Korea. SB365, Pulsatilla saponin D suppresses proliferation and induces apoptosis of pancreatic cancer cells. Cancer . Chung, Sung-Wha, et al. SB365, Pulsatilla saponin D, targets c-Met and exerts antiangiogenic and antitumor activities. It also tolerates acid, neutral and basic (alkaline) soils and can grow in very alkaline soil. Carcinogenesis. Evid Based Complement Alternat Med. 2019 Jan;55(1):7-16. doi: 10.1007/s11626-018-0294-y. 2017;2017:4198035. doi: 10.1155/2017/4198035. Deoxypodophyllotoxin; the cytotoxic and antiangiogenic component from Pulsatilla koreana. The apoptotic effect of PKE was confirmed by diamidino-2-phenylindole (DAPI) and terminal deoxynucleotidyltransferase-mediated nick end labeling (TUNEL) assay, showing apoptotic body and DNA fragmentation. 2018. Int J Oncol. According to its native range, it is likely to succeed outdoors in most areas of the country. Oncol Rep. 2017 Feb;37(2):754-760. doi: 10.3892/or.2016.5339. Kweon K, Ahn JO, Song WJ, Li Q, Lee BY, Chae HK, Youn HY. Triterpenoidal saponins of Pulsatilla koreana roots. In Vitro Cell Dev Biol Anim. Epub 2013 Jun 4. HHS Curr Genomics. 2019 Jan 9;11(1):125. doi: 10.3390/nu11010125. Complete sequence analysis and antiviral screening of medicinal plants for human coxsackievirus a16 isolated in Korea. Additionally, PKE induced apoptosis by increasing expression of cleaved PARP and caspase-3 in ATC cells. BMB Rep 45.6 (2012): 371-376. Oleanane-type triterpenoid saponins from the roots of Pulsatilla koreana and their apoptosis-inducing effects on HL-60 human promyelocytic leukemia cells. "The antimicrobial effect of Pulsatilla Koreana extracts to oral micro-organism." PULSATILLA KOREANA EXTRACT. SB365, Pulsatilla saponin D, suppresses the growth of gefitinib-resistant NSCLC cells with Met amplification. Antitumor effects of SB injection in canine osteosarcoma and melanoma cell lines. SK-PC-B70M confers anti-oxidant activity and reduces Abeta levels in the brain of Tg2576 mice. Oncol Rep. 2013 Aug;30(2):801-8. doi: 10.3892/or.2013.2517. Evaluation of the phototoxic potential of plants used in oriental medicine. Anti-angiogenic effects of water extract of a formula consisting of Pulsatilla koreana, Panax ginseng and Glycyrrhiza uralensis. Mini Rev Med Chem. Sortase A inhibitory metabolites from the roots of Pulsatilla koreana. Pulsatilla koreana, owing to its anti-inflammatory effects, is used in oriental herbal medicines.The major components of the methanol extract of Pulsatilla koreana are triterpenoid compounds and bisdesmoside. Get the latest public health information from CDC: https://www.coronavirus.gov. Epub 2017 Jun 1. Odor and/or flavor descriptions from others (if found). Anti-Angiogenic Alternative and Complementary Medicines for the Treatment of Endometriosis: A Review of Potential Molecular Mechanisms. NCI CPTC Antibody Characterization Program. Synergisic effect of APRIL knockdown and Jiedu Xiaozheng Yin, a Chinese medicinal recipe, on the inhibition of hepatocellular carcinoma cell proliferation. However, the effect of PK … "Anti-inflammatory effects of a methanol extract from Pulsatilla koreana in lipopolysaccharide-exposed rats." Classification of the substance or mixture, GHS Classification in accordance with 29 CFR 1910 (OSHA HCS), GHS Label elements, including precautionary statements. The plant prefers light (sandy) and medium (loamy) soils. Hong SW, Jung KH, Lee HS, Choi MJ, Zheng HM, Son MK, Lee GY, Hong SS.  |  Developmental & Reproductive Toxicity . Plants or herb extracts have emerged as a novel approach to controling various diseases, including cancers. New phenolic compounds with anti-adipogenic activity from the aerial parts of Pulsatilla koreana. Evid Based Complement Alternat Med. This site needs JavaScript to work properly. Hong SW, Jung KH, Lee HS, Son MK, Yan HH, Kang NS, Lee J, Hong SS. ; 37 ( 2 ):452-60. doi: 10.3892/ijo.2011.1204: apoptotic and anti-angiogenic effects of necrosis... ; 18 ( 1 ):7-16. doi: 10.1007/s11626-018-0294-y to take advantage of the set. 2012 Feb ; 37 ( 2 ):754-760. doi: 10.2174/138955751512150731113242, Ryu YL, Hong SS can in. A well-drained, humus-rich, gritty soil and a sunny position Lee GY, Hong SS (. 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