These side effects may go away during treatment as your body adjusts to the medicine. Avoid grapefruit and grapefruit juice while taking this medicine because it can increase the amount of medication in your body, which increases your risk of side effects. Older adults may be more sensitive to the side effects of this drug, especially muscle problems. Simvastatin tablets should be used as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) in these patients or if such treatments are unavailable. Simvastatin side effects. Simvastatin exposure is approximately doubled with concomitant use of lomitapide; therefore, the dose of Simvastatin tablets should be reduced by 50% if initiating lomitapide. There are some side effects associated with Simvastatin that users should be aware of 1. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. simvastatin (Zocor) Common side effects of all statins. Simvastatin (Zocor) works best if you take it in the evening since your body makes most of its cholesterol at night. Muscle pain is the most common side … This medication must not be used during pregnancy . These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. In rare cases, simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Get emergency medical help if you have any of these signs of an allergic reaction to simvastatin: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Side effects reported by some people include muscle pain and digestive problems. Simvastatin may harm an unborn baby. According to Drugs.com, Simvastatin is also used to lower the risk of stroke, heart attack, and other heart complications in people with diabetes, coronary heart disease, or other risk factors 1.