Franke J, et al. The first and most important step is to eliminate the substance that causes skeletal fluorosis, fluoride. While the earlier fluoride exposure is stopped, the better chance of reversing the effects, or even better- avoiding them entirely. However, bone made during the development of skeletal fluorosis is not of good quality compared to bone made in healthy conditions. Ligaments and cartilage can become ossified. Other symptoms include thickening of the bone structure and accumulation of bone tissue, which both contribute to impaired joint mobility. Home » Blog » Skeletal Fluorosis (Symptoms, Causes, and Prevention), Casey J Krol | Posted on March 20, 2020 |. Journal of the American Medical Association 265:486-8 [, Błaszczyk I, Birkner E, GutowskaI. For example, if a male and female with all other factors equal were exposed to the same amount of fluoride, the female would experience more severe symptoms. J Bone Miner Res 20:1032-1040 [, Amalraj A., Pius A. This is due to fluoride’s negatively charged nature that allows it to react with positively charged ions like calcium. Effect of Choline on the Composition and Degradation Enzyme of Extracellular Matrix of Mice Chondrocytes Exposed to Fluoride. In skeletal fluorosis the bones are generally weaker than normal with stiffness and pain in the joints as the early symptoms. Now there are two general steps to prevent skeletal fluorosis. It is not necessary that all symptoms are present at the same time. When fluoride intake is stopped, the amount of fluoride in bone will decrease and be excreted via urine- however, this tends to be a very slow process. doi: 10.1111/j.1365-3156.2012.03061.x. Skeletal Fluorosis is a chronic bone and joint disease caused by long term consumption of fluoride. As on average, females have less bone mass, leaving the same amount of fluoride less bone to damage. Review of Fluoride in Drinking Water, U.S. With the process of reversing skeletal fluorosis is also the same way to prevent it. As fluoride bone concentrations do not always represents the symptoms an individual experiences. Jobs exposing individuals to fluoride gas. This is true for both the early and late stages of the disease. doi: 10.1111/j.1600-0722.2011.00903.x. To further complicate matters, within the initial stages, a patient may suffer symptoms of skeletal fluorosis (joint pain, joint stiffness and gastric distress) without any detectable bone changes(17). [, Ayoob S, Gupta AK. Skeletal fluorosis is a serious condition, resulting from chronic ingestion of large amounts of fluoride over many years during periods of bone modeling (growth) and/or remodeling. As fluoride accumulates in the bones it begins to negatively alter processes of bone formation and resorption- affecting the entire skeleton(1). Fluoride in Drinking Water: A Review on the Status and Stress Effects. Since fluoride in drinking water is the largest source of fluoride, getting a water filter that removes fluoride or drinking bottled water without fluoride should be of most importance. Crippling skeletal fluorosis; mobility is significantly affected due to excessive calcification in joints, ligaments and vertebral bodies. © 2020 - Truth About Fluoride | All rights reserved, Littleton, J. But you have be like the yellow fish in the photo above and swim in the opposite direction. For example, when bone change occurs during skeletal fluorosis, it closely imitates other diseases like osteoarthritis, renal osteodystrophy, spondylosis, DISH, Paget’s Disease and osteopetrosis(11). Endemic skeletal fluorosis is a chronic metabolic bone and joint disease caused by ingesting large amounts of fluoride either through water or rarely from foods of endemic areas. Prevalence of Brick Tea-Type Fluorosis in the Tibet Autonomous Region. Symptoms are mainly promoted in the bone structure. For over 40 years, U.S. health authorities insisted that skeletal fluorosis can not develop unless a person ingests 20 milligrams of fluoride per day for over 10 years. 65(3):371-81 [, Fratzl, P., Roschger, P., Eschberger, J., Abendroth, B. and Klaushofer, K. (1994), Abnormal bone mineralization after fluoride treatment in osteoporosis: A small‐angle x‐ray‐scattering study. The early symptoms of skeletal fluorosis, include stiffness and pain in the joints. Now, here is a general guideline to gauging how much fluoride has accumulated in one’s bodies. Through this process, fluoride takes the place of naturally occurring calcium hydroxyapatite in the bone- altering normal bone formation and resorption(1). Nonetheless, there are more unique but equally detrimental sources that increase the risk of developing skeletal fluorosis: When fluoride is ingested, it is absorbed into the blood through the digestive tract. All of which points to individual susceptibility to fluoride: Considering fluoride serves no essential function in human growth or development, along with being a toxin that accumulates throughout the body. The difficulties in diagnosing skeletal fluorosis result from the questionable sensitivity of the x-ray techniques and from the non-specificity of the associated symptoms. After the teeth come in, the teeth of those affected by fluorosis may appear mildly discolored. Fluoride is a toxic substance that is prevalent in many pesticides, cavity … (2003). With diagnosis hard to pin point, the most likely diagnosis will be of conditions such as arthritis. As mentioned in, what is fluoride, the seriousness of health effects caused by fluoride toxicity depend on the following several factors: age, calcium intake, kidney function, sex, dose and duration of fluoride intake(19). J Epidemiol, 2016, 26:57–63. The guy exposing the truth about fluoride, one great article at a time. 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