(Or are they the same thing?) The Hypothesis Test for a Difference in Two Population Means. Should I use chi square test or two sample t-test? In statistics, a paired difference test is a type of location test that is used when comparing two sets of measurements to assess whether their population means differ. Paired t­test – An extremely powerful test for detecting differences (it is, in fact, the most “sensitive” of all our five tests). 8.4 Statistical Test for Difference of Population Means. Becomes more complicated if you want to test for difference between adjacent ages. As expected, the details of the conditions for use of the test and the test statistic are unique to this test (but similar in many ways to what … test applies to differences of means. One group receives a new drug, the second receives a placebo (sugar pill). Please help, because I have zero knowledge in statistics. Our last (!) Group B ages: 14, 13, 14, 12, 12, 13, 13, 12, 14, 14 --> mean age: 13.1 I would like to know whether the difference of mean age between the two groups is significant. 2. In many medical trials, for example, subjects are randomly divided into two groups. It is usually used for “Before vs. After” … What should I do? Such tests are very common when you conduct a study involving two groups. A paired difference test uses additional information about the sample that is not present in an ordinary unpaired testing situation, either to increase the statistical power, or to reduce the effects of confounders. The general steps of this hypothesis test are the same as always.